Is it a Pseudomonas Sinus infection? A Look at Pseudomonas Sinusitis

Is it a Pseudomonas Sinus infection? A Look at Pseudomonas Sinusitis

Is it a Pseudomonas Sinus Infection? Let’s take a look

A patient came to see me recently who I had treated for refractory Stenotrophomonas maltophilia sinusitis some twelve years ago. Since that time, she had been doing okay, but over the last 2-3 years, her sinuses had become much more bothersome. On several occasions, sinus cultures revealed Pseudomonas aeruginosa in the nose, sensitive to the Cipro she was prescribed, but the patient did not experience any relief and the infection persisted.

On physical exam, the nasal mucosa was found to be erythematous and swollen with purulent secretions visible.   The rest of the physical exam was non-contributory. Based on these findings, my initial concern was allergic fungal sinusitis and a DNA analysis was performed.

To my surprise, no fungus was detected, but there were some interesting findings nonetheless from the DNA analysis. Pseudomonas was a minor player in the biofilm of this patient in particular. It turned out that a majority of organisms of the biofilm were anaerobes and the true pathogens for the patient’s persistent infection.

Why were cultures growing Pseudomonas Aerunginosa in the sinus?

The reason is that anaerobes are fastidious organisms and don’t grow well on conventional, commercial medium.  So even a small amount of organisms like Pseudomonas are able to dominate and proliferate on the media and appear to be the causative agent in the infection.

This problem is then worsened by the fact that the selective pressure of the Cipro allows the anaerobes to grow unimpeded and create further damage to the sinus cavities. In addition, the biofilm is allowed to become more extensive, raising the potential for the exchange of genetic material between organisms increasing the virulence factors of the bacteria. Also, it probably was the biofilm that protected the Pseudomonas from being completely eradicated because of the glycocalyx that has the potential to shield the organisms from the effects of antibiotics.

Treating a Pseudomonas Sinus Infection

The patient was switched to clindamycin orally and is doing better. Her long-term management will include topical antibiotics that cover both anaerobes and Pseudomonas.

This case is a perfect representation of how routine cultures may not represent what are the actual pathogens in chronic infections, especially when dealing with chronic sinusitis. Not only does DNA analysis help in identifying the true pathogens, but allows for more precise antibiotic regimens to treat the infection. This will allow for better antibiotic stewardship by lessening the use of broad-spectrum antibiotics in chronic infections, which will reduce the rate of resistance by targeting the actual offending agents and not what grows the best on regular media, leading to multiple courses of antibiotics that are missing the mark.

By | 2020-08-05T12:37:49-04:00 July 27th, 2020|Chronic Sinusitis|

About the Author:

I am a passionate blogger, author, speaker and 3X Board Certified MD in Infectious Disease, Internal & Sleep Medicine. I currently am an infectious disease physician in Atlanta, GA for Infectious Disease Consultants.


  1. Avatar
    Terry Bowers April 22, 2016 at 2:09 am - Reply

    I have been treated with Cipro off and on for several years for the chronic infection of pseudomonas and also used sinus rinses of mupirocin and gentamicin. I am in remission from Rocky Mountain Spotted Fever (tick-borne illness), but I am still very ill and the sinus infection is still awful. I’ve had two sinus surgeries: 2006 and 2011. I’ve had chronic sinusitis since 1986, when I probably had the first tick bite. I was tested and was found to have Lyme disease with symptoms since 1986. Lyme was found in 2014. I had a three-month IV treatment of mupirocin and other antibiotics also in 2014. I would like to print your article to show my ENT and see if he thinks this would help me. Any comments on a treatment plan? Thanks. Terry

  2. Avatar
    Amy July 2, 2016 at 5:24 pm - Reply

    I have had frequent sinus infections for years. I had sinus surgery 6 years ago which resolved structural problems. I have chronic sinus inflammation and an abundance of chronic thick,sticky mucus (per ENT)I I also have pericarditis which resulted in an effusion(1litre blood drained) and tamponade which necessitated a pericardial window. Pathology report of the pericardium showed both chronic and acute inflammation. Repeated Allergy testing has been negative. Three years ago, I was diagnosed with undifferentiated connective tissue disease.

    My ENT recently ordered genetic sequencing testing of my infected mucous.

    staphylococcus epidermidis (MRSE)16%

    staphylococcus pseudintermedius 25%

    enterococcus faecalis 5%

    granulicatella adiacens 3%

    lactobacillus gasseri 2%

    The ENT prescribed a powdered form of vancomycin to add to a saline rinse. I am also taking oral Zyvox along with a probiotic It is my understanding that bacteria in your sinuses is normal I am hesitant to use such heavy duty antibiotics How do I know when the bacteria in the sinues is considered normal colonization vs in need of eradication? If all of the bacteria is eradicated, what replaces it? How can this cycle of frequent bacterial infections be broken?

  3. Avatar
    Amy July 2, 2016 at 5:35 pm - Reply

    The DNA sequencing also showed Staph mitis (39%) and was negative for fungus

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