Several months ago, I diagnosed a patient with antibody-specific immunoglobulin deficiency. Her chief complaint was recurrent chronic sinusitis (CRS). Besides fatigue, the patient also complained of debilitating migraines. Since she has been on IgG therapy, her migraines have been much more manageable and she is pleased to announce that her quality of life has improved significantly.
How Chronic Sinusitis Can Worsen or Trigger Migraines
Over the years, I have had several patients who believed that their underlying CRS exacerbated their migraines. Many of them asked their neurologist if there was a correlation between their CRS and their migraines and were promptly dismissed of any such nonsense. In reality, chronic sinusitis can, in fact, trigger migraines.
- Inflammation: CRS causes an increase in inflammation of the sinus cavities and the byproducts of that inflammatory process may indeed cause migraines. In addition, inflammation of the sinus cavities can also increase the pressure of the sinus cavities which can also cause an exacerbation of migraines.
- Decreased oxygen levels: CRS can cause a decrease in the airflow through the sinus cavities causing lower oxygen levels. A study conducted in 2021 showed that chronic sinusitis could decrease oxygen levels to the brain and contribute to headaches. The reduction of oxygen to the brain can alter brain activity which can contribute to headaches. Remember, oxygen therapy works in the treatment of migraines by reducing inflammation, improving blood flow to the brain, and reducing oxidative stress.
- Irritation triggers: There are multiple triggers for irritation of the nasal and sinus passages; changes in atmospheric pressure and irritants such as mold, a major concern here in the Southeast, can trigger migraines again by worsening inflammation.
The Role of IgG Therapy in Reducing Sinus Inflammation and Migraines
Immunoglobulin replacement (IgG) therapy can help by reducing inflammation in the sinus cavities. It does this by blocking inflammatory mediators, such as histamine, neutralizing autoantibodies, suppressing cell activity and promoting T-cell activity which has anti-inflammatory properties.
This is not to say that all migraines can be treated with IgG therapy, but for those who have migraines related to chronic recurring sinusitis, it could be very beneficial. If IgG could be directly introduced into the sinus cavities, it could be a breakthrough for many who suffer with migraines due to chronic sinusitis.
